Mangosteen is a tropical fruit that is associated with anti-inflammatory properties. However, research on mangosteen and psoriasis specifically is limited.

Mangosteen is a fruit derived from the Garcinia mangostana L. tree, which is native to Southeast Asia.

A key active ingredient in this fruit is a compound called xanthone. A 2023 study associated mangosteen with anti-inflammatory properties, reducing inflammatory cells and mediators in vitro and in vivo.

While related clinical studies and reviews are ongoing, it’s important to note that, to date, mangosteen has not been proven to treat any health condition. This includes psoriasis.

It is also important to note that there is no cure for psoriasis.

Mangosteen contains compounds called xanthones. According to a 2020 review, the anti-inflammatory effects of xanthones have the potential to possibly support psoriasis treatment.

The researchers also note that xanthones may be beneficial in the treatment of other skin conditions, such as:

Research on mangosteen and psoriasis specifically is limited, and not many studies include humans.

A small 2024 study found that a cream containing mangosteen peel led to significant psoriasis remission, with results observed after four weeks and sustained through eight weeks. The researchers also reported an improved quality of life.

However, it is important to note that other ingredients besides mangosteen were used in this topical cream.

While xanthones in mangosteen may potentially reduce general inflammation in autoimmune diseases like psoriasis, there is no current evidence that it can reduce the immune system activity that causes the underlying inflammation.

Like other herbal supplements, it’s not clear whether mangosteen is entirely safe for everyone.

It’s important to discuss the use of mangosteen with a doctor before you try it, especially if you’re already taking other vitamins, supplements, or medications.

It is also important to keep in mind that mangosteen is not a replacement for any medications your doctor has prescribed.

Currently, there’s not enough information available to determine whether mangosteen interacts with medications for psoriasis. However, experts caution against taking mangosteen if you take:

You should also avoid taking mangosteen if you’re undergoing radiation therapy. This is because it may interfere with the purpose of radiation.

Your doctor can advise you of potential interactions, and whether it’s safe to try mangosteen despite the lack of evidence supporting it as a psoriasis treatment.

However, additional human studies are needed to determine whether mangosteen supplements are generally safe.

Psoriasis is typically treated with a combination of prescription medications, such as:

A doctor may also recommend certain over-the-counter medications or home remedies to complement prescription psoriasis drugs. Examples include:

  • hydrocortisone creams to help reduce inflammation and itchiness
  • heavy moisturizers or ointments to help keep your skin hydrated
  • salicylic acid or lactic acid-containing products to help soften scales and reduce swelling
  • coal tar products to reduce flaking, scaling, and itching

Although the exact cause of psoriasis is unknown, avoiding common triggers may help reduce flare-ups. Some common triggers can include:

  • stress
  • skin injuries
  • illness
  • cold weather
  • alcohol consumption

Although some users may claim mangosteen is helpful in reducing inflammation, much more research needs to be done to determine whether it can provide any real relief for psoriasis. The long-term safety of mangosteen use is also unknown.

If you’re interested in adding mangosteen to your current psoriasis treatment plan, talk with a doctor first. They can help address any safety issues, including possible interactions with medications you’re currently taking.