Cobenfy (xanomeline/trospium) has potential interactions with other medications. These interactions could affect how well the drug works or cause harmful effects.
Cobenfy is used to treat schizophrenia in adults.
An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.
Keep reading to learn about Cobenfy’s possible interactions. For a detailed overview of this drug, check out this in-depth Cobenfy article.
Before you start taking Cobenfy, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions.
To learn whether Cobenfy interacts with herbs, vitamins, or supplements, see the “Are there other interactions with Cobenfy?” section.
If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.
The following table lists drugs that may interact with Cobenfy. Keep in mind this table does not include all drugs that may interact with Cobenfy. For more information about some of these interactions, see the “Drug interactions explained” section.
| Drug group or drug name | Drug examples | What can happen |
|---|---|---|
| certain antibiotics | • cefdinir • cephalexin • amoxicillin (Amoxil, Larotid) | may increase the risk of side effects from Cobenfy or the antibiotic |
| certain blood thinners | • edoxaban (Savaysa) • dabigatran (Pradaxa) | may increase the risk of side effects from the blood thinner |
| certain antidepressants | • fluoxetine (Prozac) • paroxetine (Brisdelle, Paxil, others) • bupropion (Aplenzin, Wellbutrin XL, others) | may increase the risk of side effects from Cobenfy |
| other anticholinergic drugs | • oxybutynin (Oxytrol) • diphenhydramine (Benadryl) • darifenacin | may increase the risk of side effects from Cobenfy or the other anticholinergic |
| furosemide (Furoscix, Lasix) | — | may increase the risk of side effects from Cobenfy or furosemide |
| fexofenadine (Allegra) | — | may increase the risk of side effects from fexofenadine |
| dronedarone (Multaq) | — | may increase the risk of side effects from dronedarone |
| metformin (Fortamet, Glumetza) | — | may increase the risk of side effects from Cobenfy or metformin |
| eletriptan (Relpax) | — | may increase the risk of side effects from eletriptan |
| buspirone | — | may increase the risk of side effects from buspirone |
Certain health conditions or other factors could raise your risk of harm if you take Cobenfy. In such cases, your doctor may not prescribe Cobenfy for you. These are known as contraindications. The following list includes contraindications of Cobenfy.
If you have moderate or severe liver problems: If you have a moderate or severe liver problem, such as liver failure, your doctor will likely not prescribe Cobenfy for you. These liver problems could raise the level of Cobenfy in your body. This may increase your risk of side effects from Cobenfy.
Your doctor can recommend other treatments that may be safer options for you.
If you have urinary retention: If you have urinary retention (difficulty emptying your bladder completely), your doctor will likely not prescribe Cobenfy for you. This is because the drug could worsen your condition.
Your doctor can recommend other treatment options that may be safer for you.
If you have gastric retention: If you have gastric retention (delayed stomach emptying), which is a symptom of certain conditions such as gastroparesis, your doctor will likely not prescribe Cobenfy for you. This is because the drug may worsen gastric retention.
Your doctor can recommend other treatment options that may be safe if you have this condition.
If you have untreated closed-angle glaucoma: If you have closed-angle glaucoma that has not been treated, your doctor will likely not prescribe Cobenfy for you. This is because the drug may cause dilated pupils, which could cause a sudden worsening of closed-angle glaucoma.
Your doctor can recommend other treatment options that may be safe to take if you have untreated closed-angle glaucoma.
If you’ve had an allergic reaction: If you’ve had an allergic reaction to Cobenfy or any of its ingredients, your doctor likely won’t prescribe Cobenfy for you. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.
Before you start taking Cobenfy, talk with your doctor if any of the factors mentioned here apply to you. Your doctor can determine whether Cobenfy is safe for you to take.
Cobenfy is not known to interact with alcohol. But Cobenfy and alcohol can cause some similar side effects, such as sleepiness and dizziness. So you may be more likely to experience these side effects if you drink alcohol during your Cobenfy treatment.
If you have questions about consuming alcohol while taking Cobenfy, talk with your doctor or pharmacist.
Learn more about certain drug interactions that can occur with Cobenfy.
Interaction with certain antidepressants
Cobenfy can interact with certain antidepressants, which are used to treat depression and other mental health conditions.
Certain antidepressants may increase the level of Cobenfy in your body, which could increase your risk of side effects from Cobenfy. (To learn about possible side effects of the drug, see this Cobenfy side effects article.)
Examples of antidepressants that may interact with Cobenfy include:
- fluoxetine (Prozac)
- paroxetine (Brisdelle, Paxil, others)
- bupropion (Aplenzin, Wellbutrin XL, others)
What you can do
If you take an antidepressant that interacts with Cobenfy, tell your doctor if you have severe or bothersome side effects of Cobenfy. They can determine whether it’s safe to keep taking these drugs together.
If you have questions about taking Cobenfy with antidepressants, talk with your doctor or pharmacist.
Interaction with fexofenadine
Cobenfy can interact with fexofenadine (Allegra), which is used to treat allergy symptoms.
Taking Cobenfy with fexofenadine may lead to high levels of fexofenadine in your system. This could raise your risk of side effects from fexofenadine, such as vomiting, headache, or fever.
What you can do
Before taking fexofenadine with Cobenfy, talk with your doctor. They can tell you whether it’s safe to take them together. If needed, your doctor can recommend an alternative to fexofenadine for your allergy symptoms.
If you have questions about taking Cobenfy with fexofenadine, talk with your doctor or pharmacist.
Interaction with buspirone
Cobenfy may interact with buspirone, which is used to treat anxiety.
Cobenfy may increase the level of buspirone in your body, which could raise your risk of side effects from buspirone. (To learn about the drug’s possible side effects, see this buspirone side effects article.)
What you can do
If you take Cobenfy with buspirone, watch for serious or bothersome side effects from buspirone. Your doctor can help decide if you should keep taking either drug or try an alternative.
If you have questions about taking Cobenfy with buspirone, talk with your doctor or pharmacist.
Cobenfy may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests.
Here are additional interactions that may occur with Cobenfy. Note that this is not a full list of all other possible interactions with Cobenfy.
Does Cobenfy interact with supplements?
Before you start taking Cobenfy, talk with your doctor and pharmacist about any herbs, vitamins, or supplements you take. Sharing this information with them may help you avoid possible interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Cobenfy and herbs
There are currently no reports of Cobenfy interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.
For this reason, it’s important to check with your doctor or pharmacist before taking any of these products while taking Cobenfy.
Cobenfy and vitamins
There are currently no reports of Cobenfy interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.
For this reason, it’s important to check with your doctor or pharmacist before taking any of these products while taking Cobenfy.
Does Cobenfy interact with food?
There are currently no reports of Cobenfy interacting with food.
However, it’s important to note that you should not eat food at least 2 hours before and 1 hour after taking Cobenfy. If you take Cobenfy with food, the interaction could increase your risk of side effects or affect how well Cobenfy works.
If you have other questions about Cobenfy and food, talk with your doctor or pharmacist.
Does Cobenfy interact with vaccines or lab tests?
There are currently no reports of Cobenfy interacting with vaccines or lab tests. If you have questions about receiving certain vaccines or having lab tests done during your Cobenfy treatment, talk with your doctor.
Does Cobenfy interact with cannabis or CBD?There are currently no reports of Cobenfy interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Cobenfy.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Certain medical conditions or other health factors may raise the risk of interactions with Cobenfy. Before taking Cobenfy, talk with your doctor about your health history. They’ll determine whether Cobenfy is right for you.
Health conditions or other factors that might interact with Cobenfy include:
Liver problems: If you have a liver problem, talk with your doctor before taking Cobenfy. Having a liver problem may increase your risk of side effects from Cobenfy. If you have a mild liver problem, your doctor can determine whether it’s safe to take the drug.
However, your doctor likely won’t prescribe Cobenfy for you if you have a moderate or severe liver problem. To learn more, talk with your doctor.
Urinary retention or related factors: Your doctor likely won’t prescribe Cobenfy for you if you have urinary retention. This is because the drug could worsen your condition.
Be sure to tell your doctor if you have health factors that raise your risk of urinary retention, such as an enlarged prostate. They can help you determine whether Cobenfy is a safe treatment option.
Digestive system problems: Your doctor likely won’t prescribe Cobenfy for you if you have gastric retention (delayed stomach emptying). This is because the drug may worsen your condition.
If you have a different digestive system problem, talk with your doctor before starting Cobenfy treatment. Having a digestive system problem could raise your risk of gastric retention with Cobenfy. Your doctor can determine whether Cobenfy is a safe treatment option.
Untreated closed-angle glaucoma: Your doctor likely won’t prescribe Cobenfy for you if you have untreated closed-angle glaucoma. This is because the drug may cause dilated pupils, which could cause a sudden worsening of closed-angle glaucoma.
Myasthenia gravis: If you have myasthenia gravis, talk with your doctor before taking Cobenfy. The drug may worsen symptoms of this condition. Your doctor can help determine whether Cobenfy is a safe treatment option for you.
Biliary disease: If you have a biliary disease, such as bile duct problems or gallstones, talk with your doctor before taking Cobenfy. The drug may affect your bile ducts and worsen these conditions. Your doctor can determine whether Cobenfy is a safe treatment option.
Kidney problems: If you have a kidney problem, such as kidney failure, talk with your doctor before starting Cobenfy treatment. Having a kidney problem may increase your risk of side effects from the drug. Your doctor can determine whether Cobenfy is safe for you to take.
Pregnancy: It’s not known whether Cobenfy is safe to take during pregnancy. If you’re pregnant or may become pregnant, talk with your doctor before taking Cobenfy.
If you do take Cobenfy while pregnant, consider enrolling in the drug’s pregnancy registry. This registry collects details about pregnancy issues reported with Cobenfy. To learn more, call 866-961-2388 or talk with your doctor.
Breastfeeding: It’s not known whether it’s safe to take Cobenfy while breastfeeding. If you’re breastfeeding or planning to do so, talk with your doctor about your options.
Allergic reaction: If you’ve had an allergic reaction to Cobenfy or any of its ingredients, your doctor will likely not prescribe Cobenfy. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better for you.
Taking certain steps can help you avoid interactions with Cobenfy. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:
- whether you drink alcohol or use cannabis
- the
list of medications you take, as well as any vitamins, supplements, and herbs - what to do if you start taking a new drug during your Cobenfy treatment
It’s also important to understand Cobenfy’s
If you did not get paperwork with Cobenfy, ask your pharmacist to print a copy for you. If you have trouble reading or understanding this information, your doctor or pharmacist can help.
Taking Cobenfy exactly as prescribed can also help prevent interactions.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.