Cobenfy (xanomeline and trospium chloride) can cause side effects that range from mild to serious. More common side effects include nausea, vomiting, and indigestion. If side effects become difficult to tolerate, talk with your doctor about coping tips or other treatment options.

Cobenfy is used in adults to treat schizophrenia.

Keep reading to learn about the common, mild, and serious side effects Cobenfy can cause.

Cobenfy can cause certain side effects, some more common than others. These side effects may be temporary, lasting a few days to weeks. Talk with your doctor if side effects do not go away, get worse, or become too difficult to tolerate.

Cobenfy’s commonly reported side effects include:

For more information about some of these side effects, see “Tips for managing side effects.”

Mild side effects have been reported with Cobenfy. These include:

In most cases, these side effects should be temporary, and some may be easily managed. But if you have symptoms that are ongoing or bothersome, talk with your doctor or pharmacist. Do not stop Cobenfy treatment unless your doctor recommends it.

Cobenfy may cause mild side effects other than those listed earlier. See the drug’s prescribing information for details.

For more information about some of these side effects, see “Tips for managing side effects.”

Cobenfy may cause serious side effects. The following list may not include all possible serious side effects of the drug. For more information, you can refer to Cobenfy’s prescribing information.

If you develop serious side effects while taking this medication, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Serious side effects that have been reported with Cobenfy include:

For more information about some of these side effects, see the “Tips for managing side effects” section.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Sharing your experience helps make medication safer for everyone by giving doctors and researchers more information about how the drug works in real life. If you develop a side effect during treatment with Cobenfy and want to tell the FDA about it, visit MedWatch or call 800-FDA-1088.

Allergic reaction

For some people, Cobenfy can cause an allergic reaction.

In general, symptoms of an allergic reaction can be mild or serious.

What might help

If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. They may suggest a treatment to manage your symptoms and can determine whether you should continue Cobenfy treatment.

If you have symptoms of a severe allergic reaction, such as swelling or difficulty breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care.

If your doctor confirms you’ve had a serious allergic reaction to Cobenfy, they may have you switch to a different treatment.

There may be things you can do to help make certain Cobenfy side effects more manageable. If you have ongoing, worsening, or bothersome side effects, talk with your doctor or pharmacist. They can suggest tips for managing them or recommend other available treatment options for your condition.

Nausea and vomiting

Nausea was the most common side effect reported in studies of Cobenfy. Nausea can cause vomiting and lead to dehydration.

Steps you can take to manage symptoms associated with this side effect include:

  • apply a cool compress to the back of your neck
  • drink chamomile tea, ginger tea, or peppermint tea
  • eat a small piece of fresh or candied ginger
  • recline with your upper body elevated, and move around as little as possible
  • take over-the-counter nausea medications (antiemetics) such as:
  • try the BRAT diet (bananas, rice, applesauce, and toast) or other bland foods such as:
    • saltines
    • scrambled or hard-boiled eggs
    • plain pasta or a baked potato

Always take Cobenfy with plenty of water and continue to drink water throughout each day to keep your body hydrated.

If you develop nausea that becomes severe or doesn’t go away, tell your doctor. If you’re dehydrated due to vomiting, they may suggest medical care. This may include giving you intravenous (IV) fluids (through a vein). They may also prescribe an antiemetic such as ondansetron (Zofran).

Urinary retention

Urinary retention (an inability to fully empty your bladder) was a rare side effect reported in studies of Cobenfy. People at an increased risk of this side effect include those:

  • who are 65 years or older
  • with serious bladder outlet obstruction (BOO) and incomplete bladder emptying
  • who take another muscarinic receptor blocker drug (for urinary incontinence)

Signs and symptoms of urinary retention include:

Your doctor will monitor you closely if you have a serious BOO and take Cobenfy. They’ll also follow up regularly if you take another muscarinic receptor blocker along with Cobenfy.

Tell your doctor if you have any symptoms of urinary retention. If you develop this condition, your doctor may stop your Cobenfy treatment and recommend a different schizophrenia treatment.

Before starting Cobenfy, discuss your health history with your doctor. This drug may not be right for you if you have certain medical conditions or other factors affecting your health.

Be sure to talk with your doctor if any of the following apply to you:

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.