Syfovre (pegcetacoplan) is a prescription drug used to treat geographic atrophy caused by age-related macular degeneration. The drug is given as an intravitreal injection by your doctor. It’s usually given once every 25 to 60 days.
Syfovre is used in adults to treat geographic atrophy related to age-related macular degeneration (AMD). Geographic atrophy refers to the wasting away of your retina due to AMD. This can lead to permanent vision loss.
The active ingredient in Syfovre is pegcetacoplan. Syfovre belongs to a group of drugs called complement inhibitors.
This article describes the dosage of Syfovre, as well as its strength and how it’s given. To learn more about the drug, see this in-depth Syfovre article.
The table below highlights the basics of Syfovre’s dosage. All doses are listed in milligrams (mg).
| Form | Strength | Typical Syfovre dosage |
| liquid solution that’s given as an intravitreal injection by your doctor | 150 mg/mL | 15 mg in each affected eye once every 25 to 60 days |
Keep reading for more details about Syfovre’s dosage.
What is Syfovre’s form?
Syfovre is available as a liquid solution that’s given as an intravitreal injection. This is an injection given directly into the affected eye(s).
What strength does Syfovre come in?
Syfovre comes in one strength of 150 milligrams in 1 milliliters of solution (mg/mL).
What are the usual dosages of Syfovre?
The information below describes dosages that are commonly used or recommended. In some cases, doctors may adjust your dosage from those shown below. Your doctor will prescribe a Syfovre dosage that’s appropriate for you.
Dosage for geographic atrophy caused by AMD
The typical Syfovre dosage is 15 mg injected into each affected eye once every 25 to 60 days. Your doctor will determine how often you should receive Syfovre injections. You’ll receive doses at your doctor’s office.
Syfovre is given as an intravitreal injection by your doctor. Before the injection, your doctor will numb your eye. They’ll also apply a topical antibiotic to your eye to lower your risk of infection from the injection.
Before each injection, your doctor will also check the pressure in your eye. If this pressure is high, your doctor may administer a medication to your eye to lower the pressure before giving your Syfovre injection.
You may experience temporary side effects after receiving Syfovre injections, including blurry vision and other vision problems. Your doctor will likely advise you to avoid driving, operating machinery, and other similar activities until your vision recovers after an injection. This means you may need to arrange for transportation home after your injection appointments.
Is Syfovre used long term?
Yes, Syfovre is typically used as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely receive Syfovre injections long term.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.