Key takeaways

  • Evenity’s dosage is 210 milligrams per month for a total of 12 months. Each dose consists of two injections given by a healthcare professional.
  • You’ll take calcium and vitamin D supplements with Evenity to help strengthen your bones.
  • Be sure to discuss any history of heart or blood vessel problems, such as heart attack or stroke, with your doctor before starting Evenity.

Evenity is used to treat postmenopausal osteoporosis in adult females. Doctors prescribe it to people who have a high risk of bone fractures or when other medications can’t be used or haven’t worked well.

Evenity’s active ingredient is romosozumab-aqqg.* It’s a biologic drug. While other drugs are made from chemicals, a biologic drug is made from living cells. Evenity is classified as a sclerostin blocker.

This article describes the dosage of Evenity, as well as its strength and how it’s given. To learn more about this drug, including its side effects, see this in-depth Evenity article.

Note: The use of binary terms such as “male” and “female” in this article reflects the language of the sources we’ve used. Unless otherwise noted, it’s unclear whether the research we reference included participants with expansive gender identities.

* An active ingredient is what makes a drug work. The reason “-aqqg” appears at the end of its name is to show that the drug is distinct from similar medications that may be created in the future.

This article describes dosages that are commonly used or recommended. But your doctor will determine the best dosage to fit your needs.

Evenity form

Evenity comes as a liquid solution inside prefilled syringes for injection under the skin.

Evenity strength

Each syringe contains 105 milligrams (mg) per 1.17 milliliters (mL) of solution.

Evenity dosing schedule for postmenopausal osteoporosis

The dosage of Evenity for postmenopausal osteoporosis is 210 mg once per month for 12 months.

Each syringe contains 105 mg. A complete dose is two injections, one given after the other. These injections are given by your doctor or another healthcare professional in the clinic.

Your doctor will recommend that you also take calcium and vitamin D supplements while you’re receiving Evenity injections.

Following are answers to some commonly asked questions about Evenity’s dosage.

How does the dosage of Evenity compare with the dosage of Prolia?

Both Evenity and Prolia (denosumab) are prescribed to treat postmenopausal osteoporosis. But Prolia also has other approved uses, including the treatment of osteoporosis in males.

Evenity and Prolia are both injections given under the skin. Evenity is given as two injections once per month. Prolia is given as a single injection once every 6 months.

Evenity is prescribed for 12 months. Prolia may be prescribed as a long-term treatment.

Note: The use of binary terms such as “male” and “female” in this article reflects the language of the sources we’ve used. Unless otherwise noted, it’s unclear whether the research we reference included participants with expansive gender identities.

Is there a situation where I can receive more than 12 doses of Evenity?

No, it’s unlikely that you would receive Evenity for more than 12 doses.

Evenity works mainly by increasing the growth of new bone. But this effect diminishes after 12 monthly doses.

If you and your doctor decide that you still need treatment for osteoporosis after you’ve completed treatment with Evenity, your doctor will suggest a different osteoporosis treatment. For example, they may suggest that you transition to treatment with either Prolia (denosumab) injections or Fosamax (alendronate) oral tablets.

Your doctor can provide more information about your treatment plan should you need continued treatment after 12 doses of Evenity.

Each month, you’ll receive two injections given by your doctor or another healthcare professional. The injections are given under the skin of your thigh, abdomen, or upper arm.

If you miss an Evenity injection appointment, call your doctor’s office as soon as you remember to reschedule.

How long do you take Evenity?

Evenity is used for 12 months. You’ll receive your dose once per month for a total of 12 months.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.